Acanthosis nigricans in adolescents with polycystic ovary syndrome

Background: In this study we compared the clinical and biochemical variables of adolescent females with PCOS (polycystic ovarian syndrome) its association or without acanthosis nigricans (AN).Methods: Adolescent girls (14-19 years) oligomenorrhoea hyperandrogenism were studied. Clinical parameters like blood pressure (BP), body mass index (BMI), abdominal circumference (AC), presence absence acne AN hirsutism score noted. Biochemical tests included serum total testosterone (TT), sex hormone binding globulin (SHBG) levels free androgen (FAI). Postprandial plasma insulin (PPI) glucose (PPG) measured to assess resistance tolerance respectively.Results: Significant differences observed in BMI, AC, DBP, TT FAI between two groups. The difference prevalence rate abnormal groups was insignificant. Logistic regression modelling as response variable interest SBP, level, PP PPG predictors yields testosterone, sugar, PPI, SHBG main determinants. model signifies positive impacts BMI while negative influence PPI level on AN. This analysis an evidence for a strong relation AN.Conclusions: girl is another marker obesity but not indicator underlying intolerance. Further studies are needed detect how many them ultimately develop diabetes future.